Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary.

@article{Smith2000RolesOB,
  title={Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary.},
  author={Douglas M Smith and Carina Nielsen and Clifford J Tabin and Drucilla Jane Roberts},
  journal={Development},
  year={2000},
  volume={127 17},
  pages={3671-81}
}
Patterning of the gut into morphologically distinct regions results from the appropriate factors being expressed in strict spatial and temporal patterns to assign cells their fates in development. Often, the boundaries of gene expression early in development correspond to delineations between different regions of the adult gut. For example, Bmp4 is expressed throughout the hindgut and midgut, but is not expressed in the early gizzard. Ectopic BMP4 in the gizzard caused a thinning of the… CONTINUE READING