Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.

@article{NewellLitwa2009RolesOB,
  title={Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.},
  author={Karen A. Newell-Litwa and Gloria P{\'e}rez Salazar and Yoland Smith and Victor Faundez},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 5},
  pages={
          1441-53
        }
}
Neuronal lysosomes and their biogenesis mechanisms are primarily thought to clear metabolites and proteins whose abnormal accumulation leads to neurodegenerative disease pathology. However, it remains unknown whether lysosomal sorting mechanisms regulate the levels of membrane proteins within synaptic vesicles. Using high-resolution deconvolution microscopy, we identified early endosomal compartments where both selected synaptic vesicle and lysosomal membrane proteins coexist with the adaptor… CONTINUE READING
38 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…