Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure.

@article{Basu2017RolesOA,
  title={Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure.},
  author={Ratnadeep Basu and Marko Poglitsch and Haran Yogasundaram and Jissy Thomas and Brian H. Rowe and Gavin Yadram Oudit},
  journal={Journal of the American College of Cardiology},
  year={2017},
  volume={69 7},
  pages={805-819}
}
BACKGROUND The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS is a mainstay therapy for HF. Angiotensin-converting enzyme 2 (ACE2) and its product, angiotensin 1-7 (Ang-[1-7]), are important negative regulators of the RAS. OBJECTIVES A comprehensive examination of angiotensin peptide levels and therapeutic effects of recombinant human ACE2 (rhACE2) on peptide metabolism was evaluated in human plasma and explanted heart tissue from patients with HF… CONTINUE READING
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