Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.

@article{Dalal2007RolesFT,
  title={Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.},
  author={Seema R Dalal and Michael Klemba},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 49},
  pages={35978-87}
}
During the erythrocytic stage of its life cycle, the human malaria parasite Plasmodium falciparum catabolizes large quantities of host-cell hemoglobin in an acidic organelle, the food vacuole. A current model for the catabolism of globin-derived oligopeptides invokes peptide transport out of the food vacuole followed by hydrolysis to amino acids by cytosolic aminopeptidases. To test this model, we have examined the roles of four parasite aminopeptidases during the erythrocytic cycle… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…