Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease.

@article{Krein2002RolesFI,
  title={Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease.},
  author={Peter M Krein and Brent W Winston},
  journal={Chest},
  year={2002},
  volume={122 6 Suppl},
  pages={289S-293S}
}
Idiopathic pulmonary fibrosis (IPF) is a lung disease that is characterized by epithelial cell damage and areas of denuded basement membrane resulting in inflammation, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and remodeling of alveolar gas exchange units. The progressive loss of lung gas exchange units in patients with IPF leads to respiratory failure and eventually to death. While the etiology of this disease is unknown, for many years studies suggested that… CONTINUE READING

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