Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction.

@article{Kari1999RolesFI,
  title={Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction.},
  author={Frank W. Kari and Sandra E. Dunn and John E. French and Jeffrey C. Barrett},
  journal={The journal of nutrition, health & aging},
  year={1999},
  volume={3 2},
  pages={92-101}
}
This paper focuses on the role of insulin-like growth factor-1 (IGF-1) and its associated regulatory apparatus as a key endocrine, autocrine, and paracrine signalling system involved in mediating the anti-carcinogenic activity of dietary restriction. Literature is reviewed showing that the inhibitory action of dietary restriction on carcinogenesis is global and pervasive--it is effective in several laboratory species, for a variety of tumor types, and for both spontaneous tumors and tumors… CONTINUE READING

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Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
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We found that the functional disruption of IGF-1R markedly influences breast cancer metastasis in nude mice by suppressing cellular adhesion , invasion , and metastasis of breast cancer cells to the lung , lymph nodes , and lymph vessels .
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We found that the functional disruption of IGF-1R markedly influences breast cancer metastasis in nude mice by suppressing cellular adhesion , invasion , and metastasis of breast cancer cells to the lung , lymph nodes , and lymph vessels .
We found that the functional disruption of IGF-1R markedly influences breast cancer metastasis in nude mice by suppressing cellular adhesion , invasion , and metastasis of breast cancer cells to the lung , lymph nodes , and lymph vessels .
We found that the functional disruption of IGF-1R markedly influences breast cancer metastasis in nude mice by suppressing cellular adhesion , invasion , and metastasis of breast cancer cells to the lung , lymph nodes , and lymph vessels .
We found that the functional disruption of IGF-1R markedly influences breast cancer metastasis in nude mice by suppressing cellular adhesion , invasion , and metastasis of breast cancer cells to the lung , lymph nodes , and lymph vessels .
We found that the functional disruption of IGF-1R markedly influences breast cancer metastasis in nude mice by suppressing cellular adhesion , invasion , and metastasis of breast cancer cells to the lung , lymph nodes , and lymph vessels .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
Considered together these works show that the IGF-1 pathway is uniquely poised to influence cellular transformation leading to the malignant phenotype by modulating the balance of cellular proliferation and cell death ( apoptosis ) in precancerous and cancerous cells and by influencing metastasis of nascent tumors .
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