Roles for hypoxia-regulated genes during cervical carcinogenesis: somatic evolution during the hypoxia-glycolysis-acidosis sequence.

@article{Lee2008RolesFH,
  title={Roles for hypoxia-regulated genes during cervical carcinogenesis: somatic evolution during the hypoxia-glycolysis-acidosis sequence.},
  author={Wen-Ying Lee and S E Huang and K F Hsu and C. Tzeng and Wan-Lin Shen},
  journal={Gynecologic oncology},
  year={2008},
  volume={108 2},
  pages={377-84}
}
OBJECTIVES Malignant phenotypic traits are caused by microenvironmental selection pressures during carcinogenesis. Hypoxia can drive a tumor toward a more aggressive malignant phenotype. The objective was to better understand the role of the hypoxia-regulated genes in cervical carcinogenesis. METHODS We analyzed the expression of the hypoxia-regulated genes, including hypoxia-inducible factor-1alpha (HIF-1alpha), erythropoietin (Epo), vascular endothelial growth factor (VEGF), glucose… CONTINUE READING

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