Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A.

@article{Loughman2005RolesFF,
  title={Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A.},
  author={Anthony Loughman and J Ross Fitzgerald and Marian P. Brennan and Judy A Higgins and Robert Downer and Dermot Cox and T. J. Foster},
  journal={Molecular microbiology},
  year={2005},
  volume={57 3},
  pages={804-18}
}
Staphylococcus aureus is an important cause of infective endocarditis (IE) in patients without a history of prior heart valve damage. The ability to stimulate the activation of resting platelets and their subsequent aggregation is regarded as an important virulence factor of bacteria that cause IE. Clumping factor A is the dominant surface protein responsible for platelet activation by S. aureus cells in the stationary phase of growth. This study used Lactococcus lactis as a surrogate host to… CONTINUE READING
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