Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton.

@article{Albertson2005RolesFF,
  title={Roles for fgf8 signaling in left-right patterning of the visceral organs and craniofacial skeleton.},
  author={R Craig Albertson and Pamela C Yelick},
  journal={Developmental biology},
  year={2005},
  volume={283 2},
  pages={
          310-21
        }
}
Laterality is fundamental to the vertebrate body plan. Here, we investigate the roles of fgf8 signaling in LR patterning of the zebrafish embryo. We find that fgf8 is required for proper asymmetric development of the brain, heart and gut. When fgf8 is absent, nodal signaling is randomized in the lateral plate mesoderm, leading to aberrant LR orientation of the brain and visceral organs. We also show that fgf8 is necessary for proper symmetric development of the pharyngeal skeleton. Attenuated… CONTINUE READING

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