Roles for c-Myc in self-renewal of hematopoietic stem cells.

  title={Roles for c-Myc in self-renewal of hematopoietic stem cells.},
  author={Yusuke Satoh and Itaru Matsumura and Hirokazu Tanaka and Sachiko Ezoe and Hiroyuki Sugahara and Masao Mizuki and Hirohiko Shibayama and Eri Ishiko and Jun Ishiko and Kōichi Nakajima and Yuzuru Kanakura},
  journal={The Journal of biological chemistry},
  volume={279 24},
Notch and HOXB4 have been reported to expand hematopoietic stem cells (HSCs) in vitro. However, their critical effector molecules remain undetermined. We found that the expression of c-myc, cyclin D2, cyclin D3, cyclin E, and E2F1 was induced or enhanced during Notch1- or HOXB4-induced self-renewal of murine HSCs. Since c-Myc can act as a primary regulator of G(1)/S transition, we examined whether c-Myc alone can induce self-renewal of HSCs. In culture with stem cell factor, FLT3 ligand, and IL… CONTINUE READING