Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads.

Abstract

Heterodimeric integrin receptors for extracellular matrix (ECM) play vital roles in bidirectional signaling during tissue development, organization, remodeling, and repair. The beta integrin subunit cytoplasmic domain is essential for transmission of many of these signals and overexpression of an unpaired beta tail in cultured cells inhibits endogenous… (More)

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