Roles for Fgf signaling during zebrafish fin regeneration.

  title={Roles for Fgf signaling during zebrafish fin regeneration.},
  author={Kenneth D Poss and Jie Shen and Alex Nechiporuk and Gerald McMahon and Bernard V Thisse and Christine I Thisse and Mark T. Keating},
  journal={Developmental biology},
  volume={222 2},
Following amputation of a urodele limb or teleost fin, the formation of a blastema is a crucial step in facilitating subsequent regeneration. Using the zebrafish caudal fin regeneration model, we have examined the hypothesis that fibroblast growth factors (Fgfs) initiate blastema formation from fin mesenchyme. We find that fibroblast growth factor receptor 1 (fgfr1) is expressed in mesenchymal cells underlying the wound epidermis during blastema formation and in distal blastemal tissue during… CONTINUE READING
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