Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

@article{Crossley1996RolesFF,
  title={Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development},
  author={Philip H. Crossley and George Minowada and Craig A. MacArthur and Gail Roberta Martin},
  journal={Cell},
  year={1996},
  volume={84},
  pages={127-136}
}
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The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.
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Evidence that a member of the fibroblast growth factor (FGF) family emanates from the prospective limb mesoderm to serve as an endogenous initiator for limb bud formation is provided and results suggest that FGF10 is a key mesenchymal factor involved in the initial budding as well as the continuous outgrowth of vertebrate limbs.
FGF7 and FGF10 directly induce the apical ectodermal ridge in chick embryos.
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The results suggest that FGF7 and FGF10 directly induce the AER in the ectoderm both of the flank and of the dorsal midline and that these two regions have the competence for AER induction.
Fgf8 is required for outgrowth and patterning of the limbs
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It is reported that conditional disruption of Fgf8 in the forelimb of developing mice bypasses embryonic lethality and reveals a requirement for FgF8 inThe formation of the stylopod, anterior zeugopod and autopod.
Initiation of dorso-ventral axis during chick limb development
A role for the mesenchymal T-box gene Brachyury in AER formation during limb development
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The results show that T plays a role in the regulation of AER formation, particularly maturation, and suggest that T may also be a component of the epithelialmesenchymal regulatory loop involved in maintenance of a mature functioning AER.
The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation
TLDR
It is shown that the zebrafish fgf24 gene, which belongs to the Fgf8/17/18 subfamily of FgF ligands, acts downstream of tbx5 to activate f gf10 expression in the lateral plate mesoderm, which relays the limb inducing signal to the overlying ectoderm.
Fgf10 is essential for limb and lung formation
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It is shown that Fgf10 serves as an essential regulator of lung and limb formation in mice generated with F gf10-deficient mice.
Differential response of Shh expression between chick forelimb and hindlimb buds by FGF‐4
  • N. WadaT. Nohno
  • Biology
    Developmental dynamics : an official publication of the American Association of Anatomists
  • 2001
TLDR
The difference between the fore and hindlimb buds in the cell competence of Shh induction in response to FGF‐4 is demonstrated, suggesting the possibility that the responsiveness of mesenchymal cells in signaling molecules is not the same in the fore‐ and hind Limb buds.
FGF-stimulated outgrowth and proliferation of limb mesoderm is dependent on syndecan-3.
The outgrowth of the mesoderm of the developing limb bud in response to the apical ectodermal ridge (AER) is mediated at least in part by members of the FGF family. Recent studies have indicated that…
Effects of FGFs on the morphogenic potency and AER-maintenance activity of cultured progress zone cells of chick limb bud.
TLDR
Results indicate that addition of FGF-2 or F GF-4 to cultured PZ cells maintains their competence for Hox gene expression and digit formation, but not their responsiveness to positional cues arising from the zone of polarizing activity (ZPA).
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