Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

@article{Crossley1996RolesFF,
  title={Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development},
  author={Philip H. Crossley and George Minowada and Craig A. MacArthur and Gail Roberta Martin},
  journal={Cell},
  year={1996},
  volume={84},
  pages={127-136}
}
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References

SHOWING 1-10 OF 62 REFERENCES
Fibroblast growth factors induce additional limb development from the flank of chick embryos
A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth
FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse.
TLDR
Analysis of Fgf-4 expression in the developing mouse embryo suggests that individual members of the gene family are expressed sequentially in developmental pathways such as mesoderm formation and myogenesis, and play a role in specific epithelial-mesenchymal interactions.
FGF-2: apical ectodermal ridge growth signal for chick limb development.
TLDR
Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development.
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning
Mechanisms of limb patterning.
Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system
A positive feedback loop coordinates growth and patterning in the vertebrate limb
TLDR
It is reported here that Fgf4 expression in the ridge can be regulated byshh-expressing cells, and Shh expression in mesenchyme can be activated by FGF4 in combination with retinoic acid, thus establishing a positive feedback loop between ZPA and ridge.
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