Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development
@article{Crossley1996RolesFF, title={Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development}, author={Philip H. Crossley and George Minowada and Craig A. MacArthur and Gail Roberta Martin}, journal={Cell}, year={1996}, volume={84}, pages={127-136} }
592 Citations
The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.
- BiologyDevelopmental biology
- 2004
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.
- BiologyDevelopment
- 1997
Evidence that a member of the fibroblast growth factor (FGF) family emanates from the prospective limb mesoderm to serve as an endogenous initiator for limb bud formation is provided and results suggest that FGF10 is a key mesenchymal factor involved in the initial budding as well as the continuous outgrowth of vertebrate limbs.
FGF7 and FGF10 directly induce the apical ectodermal ridge in chick embryos.
- BiologyDevelopmental biology
- 1999
The results suggest that FGF7 and FGF10 directly induce the AER in the ectoderm both of the flank and of the dorsal midline and that these two regions have the competence for AER induction.
Fgf8 is required for outgrowth and patterning of the limbs
- BiologyNature Genetics
- 2000
It is reported that conditional disruption of Fgf8 in the forelimb of developing mice bypasses embryonic lethality and reveals a requirement for FgF8 inThe formation of the stylopod, anterior zeugopod and autopod.
Initiation of dorso-ventral axis during chick limb development
- BiologyMechanisms of Development
- 2002
WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo
- BiologyCell
- 2001
A role for the mesenchymal T-box gene Brachyury in AER formation during limb development
- BiologyDevelopment
- 2003
The results show that T plays a role in the regulation of AER formation, particularly maturation, and suggest that T may also be a component of the epithelialmesenchymal regulatory loop involved in maintenance of a mature functioning AER.
The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation
- BiologyDevelopment
- 2003
It is shown that the zebrafish fgf24 gene, which belongs to the Fgf8/17/18 subfamily of FgF ligands, acts downstream of tbx5 to activate f gf10 expression in the lateral plate mesoderm, which relays the limb inducing signal to the overlying ectoderm.
Fgf10 is essential for limb and lung formation
- BiologyNature Genetics
- 1999
It is shown that Fgf10 serves as an essential regulator of lung and limb formation in mice generated with F gf10-deficient mice.
Normal limb development in conditional mutants of Fgf4.
- BiologyDevelopment
- 2000
Findings indicate that the previously proposed FGF4-SHH feedback loop is not essential for coordination of murine limb outgrowth and patterning and suggest that some of the roles currently attributed to F GF4 during early vertebrate limb development may be performed by other AER factors in vivo.
References
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