Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

@article{Crossley1996RolesFF,
  title={Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development},
  author={Philip H. Crossley and George Minowada and Craig A. MacArthur and Gail Roberta Martin},
  journal={Cell},
  year={1996},
  volume={84},
  pages={127-136}
}

Figures from this paper

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Differential response of Shh expression between chick forelimb and hindlimb buds by FGF‐4
  • N. WadaT. Nohno
  • Biology
    Developmental dynamics : an official publication of the American Association of Anatomists
  • 2001
TLDR
The difference between the fore and hindlimb buds in the cell competence of Shh induction in response to FGF‐4 is demonstrated, suggesting the possibility that the responsiveness of mesenchymal cells in signaling molecules is not the same in the fore‐ and hind Limb buds.
FGF-stimulated outgrowth and proliferation of limb mesoderm is dependent on syndecan-3.
The outgrowth of the mesoderm of the developing limb bud in response to the apical ectodermal ridge (AER) is mediated at least in part by members of the FGF family. Recent studies have indicated that
Effects of FGFs on the morphogenic potency and AER-maintenance activity of cultured progress zone cells of chick limb bud.
TLDR
Results indicate that addition of FGF-2 or F GF-4 to cultured PZ cells maintains their competence for Hox gene expression and digit formation, but not their responsiveness to positional cues arising from the zone of polarizing activity (ZPA).
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