Roles and regulation of the glutamate racemase isogenes, racE and yrpC, in Bacillus subtilis.

@article{Kimura2004RolesAR,
  title={Roles and regulation of the glutamate racemase isogenes, racE and yrpC, in Bacillus subtilis.},
  author={Keitarou Kimura and Lam-Son Phan Tran and Yoshifumi Itoh},
  journal={Microbiology},
  year={2004},
  volume={150 Pt 9},
  pages={2911-20}
}
Many bacteria, including Escherichia coli, have a unique gene that encodes glutamate racemase. This enzyme catalyses the formation of d-glutamate, which is necessary for cell wall peptidoglycan synthesis. However, Bacillus subtilis has two glutamate racemase genes, named racE and yrpC. Since racE appears to be indispensable for growth in rich medium, the role of yrpC in d-amino acid synthesis is vague. Experiments with racE- and yrpC-knockout mutants confirmed that racE is essential for growth… CONTINUE READING
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