Roles and Relationship of Macrophages and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Ischemic and Reperfused Rat Heart

@article{Kakio2000RolesAR,
  title={Roles and Relationship of Macrophages and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Ischemic and Reperfused Rat Heart},
  author={Tadashi Kakio and Akira Matsumori and Koh Ono and Haruyasu Ito and Kouji Matsushima and Shigetake Sasayama},
  journal={Laboratory Investigation},
  year={2000},
  volume={80},
  pages={1127-1136}
}
Reperfusion injury is a troublesome and unresolved problem in acute myocardial infarction and is believed to be associated with inflammatory reactions in which various types of cells and cytokines participate, in particular, macrophages and monocyte chemoattractant protein-1 (MCP-1). We designed this study to clarify the role and relationship of macrophages and MCP-1 in ischemic and reperfused heart. The number and distribution of macrophages and MCP-1 messenger RNA (mRNA) in the ischemic and… CONTINUE READING

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