Role reversal: the regulation of neuronal gene expression by microRNAs

@article{Klein2005RoleRT,
  title={Role reversal: the regulation of neuronal gene expression by microRNAs},
  author={Matthew E. Klein and Soren Impey and Richard H. Goodman},
  journal={Current Opinion in Neurobiology},
  year={2005},
  volume={15},
  pages={507-513}
}
In a similar fashion to transcription factors, non-coding RNAs can be essential regulators of gene expression. The largest class of non-coding RNAs is the microRNAs. These approximately 22 nt double-stranded RNA molecules can repress translation or target mRNA degradation. There has been a surge of research in the past year stimulated by the recent availability of specialized techniques, both in vitro and in silico, for predicting and characterizing microRNAs. The accumulating evidence suggests… Expand
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