Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs

Abstract

We have investigated the effects of SR-48968, an NK2 receptor antagonist, and indomethacin, a cyclooxygenase inhibitor, against bronchoconstriction and airway microvascular leakage induced by bradykinin (BK) in anesthetized guinea pigs. In addition, we have determined whether these effects were mediated via bradykinin B2 receptor activation, using a B2… (More)
DOI: 10.1007/BF01998962

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@article{Sakamoto1993RolePB, title={Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs}, author={Tatsuo Sakamoto and Hideo Tsukagoshi and Peter J Barnes and Kian Fan Chung}, journal={Agents and Actions}, year={1993}, volume={39}, pages={111-117} }