Role of zinc in protection against cadmium-induced toxicity in formation of embryonic chick bone in tissue culture.

@article{Kaji1988RoleOZ,
  title={Role of zinc in protection against cadmium-induced toxicity in formation of embryonic chick bone in tissue culture.},
  author={Toshiyuki Kaji and Michiyo Takata and Takashi Hoshino and Tatsuro Miyahara and Hiroshi Kozuka and Yoshihito Kurashige and Fumihito Koizumi},
  journal={Toxicology letters},
  year={1988},
  volume={44 1-2},
  pages={219-27}
}
To clarify a possible mechanism of zinc (Zn)-induced tolerance to cadmium (Cd) toxicity on bone formation, femurs from 9-day-old chick embryos were cultured for 6 days by the roller-tube method in the presence of Cd (2, 4 or 9 microM) and/or Zn (60 microM). Zn prevented a decrease in bone growth caused by Cd at 4 and 9 microM. An increase in calcium (Ca) content of diaphysis was inhibited by Zn in both the presence and absence of Cd. Histologically, Zn protected a Cd-induced degenerative change… CONTINUE READING

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