Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .

Abstract

In previous studies [Delker, S. L., et al. (2010), J. Am. Chem. Soc. 132, 5437-5442], we determined the crystal structures of neuronal nitric oxide synthase (nNOS) in complex with nNOS-selective chiral pyrrolidine inhibitors, designed to have an aminopyridine group bound over the heme where it can electrostatically interact with the conserved active site… (More)
DOI: 10.1021/bi1013479

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Cite this paper

@article{Delker2010RoleOZ, title={Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .}, author={Silvia L Delker and Fengtian Xue and Huiying Li and Joumana Jamal and Richard B Silverman and Thomas L Poulos}, journal={Biochemistry}, year={2010}, volume={49 51}, pages={10803-10} }