Role of xanthine oxidase in ischemia/reperfusion injury.

  title={Role of xanthine oxidase in ischemia/reperfusion injury.},
  author={Stuart L. Linas and D Whittenburg and John E. Repine},
  journal={The American journal of physiology},
  volume={258 3 Pt 2},
Oxygen metabolites formed during reperfusion of ischemic kidneys prevent recovery of renal function after short periods of renal ischemia. Xanthine oxidase has been proposed as a source of toxic oxygen metabolites during reperfusion of ischemic kidneys. To determine whether the enzyme is converted from the non-oxygen metabolite-producing dehydrogenase (type D) to the oxygen metabolite-producing oxidase (type O), we measured type D and type O (total, reversible, and irreversible) xanthine… CONTINUE READING

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