Role of xanthine oxidase-derived oxidants and leukocytes in ethanol-induced jejunal mucosal injury

@article{Dinda1996RoleOX,
  title={Role of xanthine oxidase-derived oxidants and leukocytes in ethanol-induced jejunal mucosal injury},
  author={Partosh K. Dinda and Plamen Kossev and Ivan Thomas Beck and M. A. Costarellam C. G. Buell},
  journal={Digestive Diseases and Sciences},
  year={1996},
  volume={41},
  pages={2461-2470}
}
Previous reports indicate that intestinal intraluminal ethanol increases mucosal permeability (an index of mucosal injury) and histamine release by mast cells, and that the released histamine plays a role in mediating the increased permeability. In the present study, we investigated whether reactive oxygen metabolites and their major sources (xanthine oxidase and leukocytes) were involved in these ethanol effects. In rabbits, segments of the jejunum were perfused with a control solution or with… CONTINUE READING

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