Role of vitamin D3 in regulation of T helper cell 17 and regulatory T-cell balance in rats with immunoglobulin a nephropathy.

@article{Zhang2014RoleOV,
  title={Role of vitamin D3 in regulation of T helper cell 17 and regulatory T-cell balance in rats with immunoglobulin a nephropathy.},
  author={Xinging Zhang and Xiao-Chuan Wu and Lan Xiong and Zhuwen Yi and Qingnan He and Xiao-jie He and Shuanghong Mo},
  journal={Iranian journal of kidney diseases},
  year={2014},
  volume={8 5},
  pages={363-70}
}
INTRODUCTION Dysregulation of CD4+ T cell subsets participates in the pathogenesis of immunoglobulin A nephropathy (IgAN). Vitamin D has immunomodulatory functions. This study aims to investigate the regulatory effect of vitamin D3 on T helper- regulatory T (Th17-Treg) cells balance in rats with IgAN. MATERIALS AND METHODS Sprague-Dawley rats were randomly assigned to a normal group (n = 6), an IgAN model group (n = 5), a prednisone treatment IgAN group (n = 6), a 1,25-dihydroxyvitamin D3… CONTINUE READING