Role of vitamin C as an adjuvant therapy to different iron chelators in young β-thalassemia major patients: efficacy and safety in relation to tissue iron overload.

@article{Elalfy2016RoleOV,
  title={Role of vitamin C as an adjuvant therapy to different iron chelators in young β-thalassemia major patients: efficacy and safety in relation to tissue iron overload.},
  author={Mohsen Saleh Elalfy and Maha M. Saber and Amira A Adly and Eman Abdel Rahman Ismail and Mohamed Tarif and Fatma Ibrahim and Omar M Elalfy},
  journal={European journal of haematology},
  year={2016},
  volume={96 3},
  pages={
          318-26
        }
}
BACKGROUND Vitamin C, as antioxidant, increases the efficacy of deferoxamine (DFO). AIM To investigate the effects of vitamin C as an adjuvant therapy to the three used iron chelators in moderately iron-overloaded young vitamin C-deficient patients with β-thalassemia major (β-TM) in relation to tissue iron overload. METHODS This randomized prospective trial that included 180 β-TM vitamin C-deficient patients were equally divided into three groups (n = 60) and received DFO, deferiprone (DFP… CONTINUE READING