Role of visual pigment properties in rod and cone phototransduction

@article{Kefalov2003RoleOV,
  title={Role of visual pigment properties in rod and cone phototransduction},
  author={Vladimir J Kefalov and Yingbin Fu and Nicholas Marsh-Armstrong and K. K. C. Yau},
  journal={Nature},
  year={2003},
  volume={425},
  pages={526-531}
}
Retinal rods and cones share a phototransduction pathway involving cyclic GMP. Cones are typically 100 times less photosensitive than rods and their response kinetics are several times faster, but the underlying mechanisms remain largely unknown. Almost all proteins involved in phototransduction have distinct rod and cone variants. Differences in properties between rod and cone pigments have been described, such as a 10-fold shorter lifetime of the meta-II state (active conformation) of cone… CONTINUE READING

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