Role of viral vectors and virion shells in cellular gene expression.

  title={Role of viral vectors and virion shells in cellular gene expression.},
  author={Jackie L. Stilwell and Richard Jude Samulski},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={9 3},
The role of the virion shell in viral pathogenesis is relatively unknown yet the use of viral vectors in human gene transfer experiments requires an understanding of these interactions. In this study, we used DNA microarrays to identify genes modulated during pathogenic adenovirus or nonpathogenic adeno-associated virus infections. Responses to wt viruses, recombinant vectors, or empty virion particles were compared. Adeno-associated virus shells induced nearly the full complement of changes… CONTINUE READING


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