Role of viral regulatory and accessory proteins in HIV-1 replication.

@article{Seelamgari2004RoleOV,
  title={Role of viral regulatory and accessory proteins in HIV-1 replication.},
  author={Anila Seelamgari and Anil Maddukuri and Reem G Berro and Cynthia de la Fuente and Kylene W. Kehn and Longwen Deng and Shabnam Dadgar and Maria Elena Bottazzi and Elodie Ghedin and Anne Pumfery and Fatah Kashanchi},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2004},
  volume={9},
  pages={
          2388-413
        }
}
Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired immune deficiency syndrome (AIDS), a disease characterized by CD4+ T lymphocyte depletion. HIV-1 replicates actively in a variety of cells by encoding several regulatory (Tat and Rev) and accessory (Vpr, Vif, Vpu, and Nef) proteins. Accessory proteins, thought initially to be dispensable for infection, have now been shown to be important for efficient infection in vivo. Recent evidence suggests that certain viral proteins… CONTINUE READING

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