Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze.

@article{Calixto2010RoleOV,
  title={Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze.},
  author={Ana Valqu{\'i}ria Calixto and Filipe Silveira Duarte and Marcelo Duzzioni and Luciane Pereira Nascimento H{\"a}ckl and Moacir Serralvo Faria and Thereza C M De lima},
  journal={Behavioural brain research},
  year={2010},
  volume={207 1},
  pages={112-7}
}
The L-arginine/nitric oxide (NO)/cGMP pathways have been implicated in the control of a variety of physiological mechanisms and are believed to participate in the modulation of anxiety in the CNS. The aim of this study was to investigate the effects of N(G)-nitro-L-arginine-methyl-ester (L-NAME), a non-selective inhibitor of NO synthase (NOS); 7-nitroindazole (7-NI), a preferential inhibitor of neuronal NOS; and sodium nitroprusside (SNP), an NO donor, administered into the ventral hippocampus… CONTINUE READING
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