Role of vasoactive intestinal polypeptide in the adaptation of intestinal smooth muscle cells to mechanical distension.

@article{Rekik1998RoleOV,
  title={Role of vasoactive intestinal polypeptide in the adaptation of intestinal smooth muscle cells to mechanical distension.},
  author={Monique Rekik and Michel M Delvaux and Jacques Frexinos and Lionel Bu{\'e}no},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 3},
  pages={832-8}
}
Distension of the small intestine can play a role in the pathogenesis of various functional intestinal disorders. This study determined the role of vasoactive intestinal polypeptide (VIP) in the adaptative response of intestinal smooth muscle to acute and chronic distension of the ileum in vivo. Several in vitro experiments were performed to identify the mechanism of receptor regulation. Distension was applied by a balloon inflated with air in the ileum either during a single episode in… CONTINUE READING

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1 Excerpt

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