Role of vascular endothelial growth factor and angiopoietin 1 in renal injury in hemolytic uremic syndrome.

@article{Ohara2012RoleOV,
  title={Role of vascular endothelial growth factor and angiopoietin 1 in renal injury in hemolytic uremic syndrome.},
  author={Shinichiro Ohara and Yukihiko Kawasaki and Yusaku Abe and Masahiro Watanabe and Atsushi Ono and Kazuhide Suyama and Koichi Hashimoto and Takashi Honda and Junzo Suzuki and Mitsuaki Hosoya},
  journal={American journal of nephrology},
  year={2012},
  volume={36 6},
  pages={516-23}
}
BACKGROUND/AIMS The recovery process from renal injury in hemolytic uremic syndrome (HUS) remains obscure. In order to clarify the role of vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang-1) in the renal recovery from HUS, we produced a model of mild HUS and examined the renal recovery process. METHODS We investigated three groups of mice. Group 1 consisted of mice that received an injection of Shiga toxin 2 (Stx2) and lipopolysaccharide (LPS); group 2 consisted of mice that… CONTINUE READING