Role of upstream stimulatory factors in regulation of renal transforming growth factor-beta1.

@article{Zhu2005RoleOU,
  title={Role of upstream stimulatory factors in regulation of renal transforming growth factor-beta1.},
  author={Yanqing Zhu and M. Sanchez Casado and Sophie Vaulont and Kumar Sharma},
  journal={Diabetes},
  year={2005},
  volume={54 7},
  pages={1976-84}
}
We previously identified an E-box to be implicated in high-glucose-induced transforming growth factor-beta1 (TGF-beta1) gene stimulation in murine mesangial cells. In the present study, we evaluated the role of upstream stimulatory factors (USFs) in mediating glucose-induced stimulation of TGF-beta1. Mesangial cells cultured in glucose concentrations exceeding 2.7 mmol/l D-glucose exhibited increased levels of USF1 and USF2 protein by Western analysis and electrophoretic mobility shift assay… CONTINUE READING

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References

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Showing 1-10 of 44 references

Familial combined hyperlipidemia is associated with upstream stimulatory factor 1 (USF1)

  • P Pajukanata, H Lilja, +11 authors L Peltonen
  • Nat Genet 36:371–376,
  • 2004

Glucose upregulates thrombospondin 1 gene transcription and TGF-b activity through antagonism of PKG repression via upstream stimulatory factor 2

  • S Wang, J Skoreczewski, L Feng, L Mei, JE Murphy-Ullrich
  • J Biol Chem 279:34311–34322,
  • 2004

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