Role of up-regulation of IK1 in action potential shortening associated with atrial fibrillation in humans.

@article{Zhang2005RoleOU,
  title={Role of up-regulation of IK1 in action potential shortening associated with atrial fibrillation in humans.},
  author={Henggui Zhang and Clifford J. Garratt and Jiujiang Zhu and Arun V. Holden},
  journal={Cardiovascular research},
  year={2005},
  volume={66 3},
  pages={493-502}
}
OBJECTIVES Although previous studies in dogs have indicated a minimal role for changes in I(K1) in the shortening of action potential duration (APD) associated with atrial fibrillation (AF), in humans, there is evidence for significant AF-induced up-regulation of this current. In this computer model study, we investigated the relative contributions of the remodeling of I(K1), L-type calcium current, and other remodeled ionic channel currents to AF-induced APD reduction in human atrium… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Similar Papers

Loading similar papers…