Role of unique basic residues in cytotoxic, antibacterial and antiparasitic activities of human eosinophil cationic protein.

@article{Singh2011RoleOU,
  title={Role of unique basic residues in cytotoxic, antibacterial and antiparasitic activities of human eosinophil cationic protein.},
  author={Anubha Singh and Janendra K. Batra},
  journal={Biological chemistry},
  year={2011},
  volume={392 4},
  pages={337-46}
}
Eosinophil granule proteins, eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin are members of the RNase A superfamily, which play a crucial role in host defense against various pathogens as they are endowed with several biological activities. Some of the biological activities possessed by ECP have been attributed to its strong basic character. In the current study, we have investigated the role of five unique basic residues, Arg22, Arg34, Arg61, Arg77 and His64 of ECP in its… CONTINUE READING