Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning.

@article{Ozcan2013RoleOU,
  title={Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning.},
  author={Cevher Ozcan and Monica Palmeri and Tam{\'a}s L. Horv{\'a}th and Kerry Russell and Raymond R. Russell},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={304 9},
  pages={H1192-200}
}
Overexpression of mitochondrial uncoupling proteins (UCPs) attenuates ischemia-reperfusion (I/R) injury in cultured cardiomyocytes. However, it is not known whether UCPs play an essential role in cardioprotection in the intact heart. This study evaluated the cardioprotective efficacy of UCPs against I/R injury and characterized the mechanism of UCP-mediated protection in addition to the role of UCPs in ischemic preconditioning (IPC). Cardiac UCP3 knockout (UCP3(-/-)) and wild-type (WT) mice… CONTINUE READING

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