Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.

@article{Nystrm2009RoleOT,
  title={Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.},
  author={Alexander Nystr{\"o}m and Zabeena P Shaik and Donald Gullberg and Thomas Krieg and Beate Eckes and Roy Zent and Ambra Pozzi and Renato V Iozzo},
  journal={Blood},
  year={2009},
  volume={114 23},
  pages={4897-906}
}
Endorepellin, the C-terminal domain of perlecan, is a powerful angiogenesis inhibitor. To dissect the mechanism of endorepellin-mediated endothelial silencing, we used an antibody array against multiple tyrosine kinase receptors. Endorepellin caused a widespread reduction in phosphorylation of key receptors involved in angiogenesis and a concurrent increase in phosphatase activity in endothelial cells and tumor xenografts. These effects were efficiently hampered by function-blocking antibodies… CONTINUE READING

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A role for α11β1 integrin in the human periodontal ligament

  • MM Barczyk, L-H Borge Olsen, P da Franca
  • J Dent Res
  • 2009

Cross-talk between integrins α1β1 and α2β1 in renal epithelial cells

  • TD Abair, M Sundaramoorthy, D Chen
  • Exp Cell Res
  • 2008

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