Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells.

@article{Distefano2002RoleOT,
  title={Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells.},
  author={Enza Distefano and Maria Marino and Jennifer A Gillette and Bettina Hanstein and Valentina Pallottini and Jens Br{\"u}ning and Wilhelm Krone and Anna Trentalance},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1580 2-3},
  pages={145-9}
}
The expression of the low-density lipoprotein receptor (LDL-r) gene is stimulated by estrogen in vivo, although its promoter does not contain a classical estrogen-responsive element, suggesting an alternative mechanism of estrogen-regulated expression of this gene. The aim of this work was to assess whether estrogen-stimulated transcription of the LDL-r gene depends on tyrosine kinase (TK) and protein kinase C (PKC) activation, both signaling pathways being activated by estrogen in vivo and in… CONTINUE READING

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