Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway.

@article{Cunnick1998RoleOT,
  title={Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway.},
  author={Jess M. Cunnick and Jay F. Dorsey and Thomas D. A. Standley and James Turkson and Alan J. Kraker and David W. Fry and Richard Jove and Jie Wu},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 23},
  pages={14468-75}
}
Recent evidence indicates that the epidermal growth factor (EGF) receptor mediates a branch of lysophosphatidic acid (LPA)-induced signal transduction pathways that activate mitogen-activated protein (MAP) kinase. However, it is unclear whether the intrinsic tyrosine kinase activity of EGF receptor is involved. We previously showed that reactive oxygen species (ROS) were involved in the LPA-stimulated MAP kinase pathway. Here, we identify tyrosine phosphorylation of EGF receptor as an LPA… CONTINUE READING

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