Role of type IV secretion in Helicobacter pylori pathogenesis

  title={Role of type IV secretion in Helicobacter pylori pathogenesis},
  author={S. Backert and M. Selbach},
  journal={Cellular Microbiology},
  • S. Backert, M. Selbach
  • Published 2008
  • Biology, Medicine
  • Cellular Microbiology
  • Helicobacter pylori is a highly successful human‐specific gastric pathogen that colonizes more than half the world's population. Infection with this bacterium can induce gastric pathologies ranging from chronic gastritis to peptic ulcers and even cancer. Virulent H. pylori isolates harbour the cag (cytotoxin‐associated genes) pathogenicity island, a 40 kb stretch of DNA that encodes components of a type IV secretion system (T4SS). This T4SS forms a pilus for the injection of virulence factors… CONTINUE READING
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