Role of type I myosins in receptor-mediated endocytosis in yeast.

  title={Role of type I myosins in receptor-mediated endocytosis in yeast.},
  author={M Isabel Geli and Howard Riezman},
  volume={272 5261},
Type I myosins are thought to drive actin-dependent membrane motility, but the direct demonstration in vivo of their involvement in specific cellular processes has been difficult. Deletion of the genes MYO3 and MYO5, which encode the yeast type I myosins, almost abolished growth. A double-deleted mutant complemented with a MYO5 temperature-sensitive allele (myo5-1) showed a strong defect in the internalization step of receptor-mediated endocytosis, whereas the secretory pathway remained… CONTINUE READING

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