Role of type I interferons in the activation of autoreactive B cells.

@article{Kiefer2012RoleOT,
  title={Role of type I interferons in the activation of autoreactive B cells.},
  author={Kerstin Kiefer and Michael A. Oropallo and Michael P. Cancro and Ann Marshak-Rothstein},
  journal={Immunology and cell biology},
  year={2012},
  volume={90 5},
  pages={
          498-504
        }
}
Type I interferons (IFNs) are a family of cytokines involved in the defense against viral infections that play a key role in the activation of both the innate and adaptive immune system. IFNs both directly and indirectly enhance the capacity of B lymphocytes to respond to viral challenge and produce cytotoxic and neutralizing antibodies. However, prolonged type I IFN exposure is not always beneficial to the host. If not regulated properly IFN can drive autoantibody production as well as other… CONTINUE READING
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