Role of type 1 and type 2 T helper cells in allergic diseases.


Various characteristics of atopic allergic disorders seem to be causally related with the activation of allergen-specific T helper lymphocytes with a type 2 cytokine secretion profile, including high levels of interleukin-4 and interleukin-5. These cytokines are responsible for the occurrence of elevated levels of serum allergen-specific IgE and eosinophilia and play an important role in local inflammatory reactions.


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@article{Kapsenberg1992RoleOT, title={Role of type 1 and type 2 T helper cells in allergic diseases.}, author={Martien L. Kapsenberg and Henk M . Jansen and Jan Dositheus Bos and Eddy A. Wierenga}, journal={Current opinion in immunology}, year={1992}, volume={4 6}, pages={788-93} }