Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives.

@article{Win2015RoleOT,
  title={Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives.},
  author={Aung Ko Win and Daniel D Buchanan and Christophe Rosty and Robert J MacInnis and James G. Dowty and Gillian S. Dite and Graham G. Giles and Melissa C. Southey and Joanne P. Young and Mark Clendenning and M. D. Walsh and Rhiannon J. Walters and Alex Boussioutas and Thomas C. Smyrk and Stephen N. Thibodeau and John A. Baron and John D. Potter and Polly A Newcomb and Lo{\"i}c Le Marchand and Robert W Haile and Steven J Gallinger and Noralane M. Lindor and John L. Hopper and Dennis J. Ahnen and Mark A Jenkins},
  journal={Gut},
  year={2015},
  volume={64 1},
  pages={101-10}
}
OBJECTIVE To estimate risk of colorectal cancer (CRC) for first-degree relatives of CRC cases based on CRC molecular subtypes and tumour pathology features. DESIGN We studied a cohort of 33,496 first-degree relatives of 4853 incident invasive CRC cases (probands) who were recruited to the Colon Cancer Family Registry through population cancer registries in the USA, Canada and Australia. We categorised the first-degree relatives into four groups: 28,156 of 4095 mismatch repair (MMR)-proficient… CONTINUE READING
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Family history of colorectal cancer in BRAF p . V 600 E mutated colorectal cancer cases

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Somatic mutations in MLH 1 and MSH 2 are a Frequent Cause of Mismatch - repair De fi ciency in Lynch Syndrome - like Tumors

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