Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide.

  title={Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide.},
  author={C. Fearns and D. Loskutoff},
  journal={Infection and immunity},
  volume={65 11},
  • C. Fearns, D. Loskutoff
  • Published 1997
  • Biology, Medicine
  • Infection and immunity
  • We previously demonstrated CD14 gene expression in myeloid and epithelial cells of the mouse and showed that expression of the CD14 gene in both is modulated by lipopolysaccharide (LPS). Here we test the hypothesis that the induction of CD14 in these cells is an indirect effect of LPS, one mediated by tumor necrosis factor alpha (TNF-alpha). TNF-alpha induced a transient increase in levels of CD14 in plasma with a peak at 6 to 8 h, and this increase in levels of CD14 antigen in plasma was… CONTINUE READING
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