Role of tumor cell surface lysosome-associated membrane protein-1 (LAMP1) and its associated carbohydrates in lung metastasis

@article{Agarwal2015RoleOT,
  title={Role of tumor cell surface lysosome-associated membrane protein-1 (LAMP1) and its associated carbohydrates in lung metastasis},
  author={Akhil Kumar Agarwal and Nithya Srinivasan and Rashmi Godbole and Shyam K. More and Srikanth Budnar and Rajiv P. Gude and Rajiv D. Kalraiya},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2015},
  volume={141},
  pages={1563-1574}
}
AbstractPurpose Expression of lysosome-associated membrane protein-1 (LAMP1) on the surface correlates with metastatic potential of B16 melanoma cells. Downregulation of their expression in high metastatic (B16F10) cells reduced their surface expression and metastatic potential. Present investigations explore if overexpression of LAMP1 on the surface of low metastatic (B16F1) cells augment their metastatic ability, and if so, how?MethodsB16F1 cells were transduced with lentiviral vector… 

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