Role of tumor cell surface lysosome-associated membrane protein-1 (LAMP1) and its associated carbohydrates in lung metastasis

@article{Agarwal2015RoleOT,
  title={Role of tumor cell surface lysosome-associated membrane protein-1 (LAMP1) and its associated carbohydrates in lung metastasis},
  author={Akhil Kumar Agarwal and Nithya Srinivasan and Rashmi Godbole and Shyam K. More and Srikanth Budnar and Rajiv P. Gude and Rajiv D. Kalraiya},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2015},
  volume={141},
  pages={1563-1574}
}
AbstractPurpose Expression of lysosome-associated membrane protein-1 (LAMP1) on the surface correlates with metastatic potential of B16 melanoma cells. Downregulation of their expression in high metastatic (B16F10) cells reduced their surface expression and metastatic potential. Present investigations explore if overexpression of LAMP1 on the surface of low metastatic (B16F1) cells augment their metastatic ability, and if so, how?MethodsB16F1 cells were transduced with lentiviral vector… 
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LAMP1 expression is associated with poor prognosis in breast cancer

TLDR
The results suggested that LAMP1 expression is associated with malignant attributes of BC and may serve as a novel prognostic factor for patients with BC.

Altered expression of lysosomal associated membrane protein 1 in esophageal squamous cell carcinoma.

LAMP-3 (Lysosome-Associated Membrane Protein 3) Promotes the Intracellular Proliferation of Salmonella typhimurium

TLDR
It is concluded that LAMP-3 is induced by Salmonella infection and recruited to theSalmonella pathogen for intracellular proliferation.

UBL 4 A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP 1

TLDR
A novel mechanism of UBL4A is described that suppresses the progression of pancreatic cancer and might be a promising target for the treatment and prognostication of PDAC.

UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1

TLDR
A novel mechanism of UBL4A is described that suppresses the progression of pancreatic cancer and might be a promising target for the treatment and prognostication of PDAC.

TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2

TLDR
The results indicate that TSTA3 may be a driver of ESCC metastasis through regulating fucosylation of LAMP2 and ERBB2, thereby inhibiting ESCC cell invasion.

High expression of LAMP2 predicts poor prognosis in patients with esophageal squamous cell carcinoma.

TLDR
It is demonstrated that high expression of LAMP2 predicts poor prognosis in patients with ESCC and expression levels correlated with tumor histological differentiation and TNM stages.

LAMP1 expression is associated with malignant behaviours and predicts unfavourable prognosis in laryngeal squamous cell carcinoma.

LAMPs: Shedding light on cancer biology.

TLDR
Different examples about how LAMP proteins can influence and support tumor growth and metastatic spread are presented, emphasizing the impact of each single member of the family.

Galectin-3-induced cell spreading and motility relies on distinct signaling mechanisms compared to fibronectin

TLDR
Different signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 as opposed to fibronectin are demonstrated.

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