Role of tumor cell apoptosis in tumor antigen migration to the draining lymph nodes.

@article{Bonnotte2000RoleOT,
  title={Role of tumor cell apoptosis in tumor antigen migration to the draining lymph nodes.},
  author={Bernard Bonnotte and Nathalie Favre and Monique Moutet and Annie Fromentin and {\'E}ric Solary and Margarita Mart{\'i}n and François Martin},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={1995-2000}
}
Establishment of an immune response against cancer may depend on the capacity of dendritic cells to transfer tumor Ags into T cell-rich areas. To check this possibility, we used a colon cancer cell variant that yields tumors undergoing complete T cell-dependent rejection when injected into syngeneic rats. We previously demonstrated that immunogenicity of these tumors depended on the early apoptosis of a part of these tumor cells. In this paper we show that fluorescent tumor cell proteins are… CONTINUE READING

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