Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis.


L-Arginine is one of the precursor amino acids of polyamine biosynthesis in most living organisms including Leishmania parasites. L-Arginine is enzymatically hydrolyzed by arginase producing L-ornithine and urea. In Leishmania spp. and other trypanosomatids a single gene encoding arginase has been described. The product of this gene is compartmentalized in… (More)
DOI: 10.1016/j.molbiopara.2011.10.007


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