Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies.

  title={Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies.},
  author={Hanna Debiec and Jeroen Nauta and Florence Coulet and Mirjam van der Burg and Vincent Guigonis and Thierry Schurmans and Emile de Heer and Florent Soubrier and Françoise Janssen and Pierre Ronco},
  volume={364 9441},
BACKGROUND Membranous glomerulonephritis is an immune-mediated disease. In a recent case of antenatal membranous glomerulonephritis, we identified neutral endopeptidase (NEP) as the podocyte target antigen of circulating antibodies produced by the mother who failed to express NEP on granulocytes. We aimed to investigate whether the disease could affect other families, to search for mutations in the metallomembrane endopeptidase (MME) gene for NEP, and to analyse the outcome of the antenatal… CONTINUE READING
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