Role of trehalose in resistance to macrophage killing: study with a tps1/tps1 trehalose-deficient mutant of Candida albicans.

@article{MartnezEsparza2007RoleOT,
  title={Role of trehalose in resistance to macrophage killing: study with a tps1/tps1 trehalose-deficient mutant of Candida albicans.},
  author={Mar{\'i}a Concepci{\'o}n Mart{\'i}nez-Esparza and Ana Aguinaga and Pilar G{\'o}nzalez-P{\'a}rraga and Pilar Garc{\'i}a-Pe{\~n}arrubia and Thierry Jouault and Juan Carlos Arg{\"u}elles},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  year={2007},
  volume={13 4},
  pages={384-94}
}
Accumulation of trehalose by yeast is an important protective mechanism against different stress conditions. This study examined the effect of trehalose on several growth features, as well as its association with the intracellular survival of yeasts exposed to macrophages. A tps1/tps1 mutant and its parental counterpart, CAI4, exhibited similar growth rates and preserved their dimorphic conversion and agglutination ability. However, electron-microscopy of cell-wall architecture showed a partial… CONTINUE READING

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