Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans.

@article{MartnezEsparza2009RoleOT,
  title={Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans.},
  author={Mar{\'i}a Mart{\'i}nez-Esparza and Encarnaci{\'o}n Mart{\'i}nez-Vicente and Pilar G{\'o}nzalez-P{\'a}rraga and Jos{\'e} Mar{\'i}a Ros and Pilar Garc{\'i}a-Pe{\~n}arrubia and J. Arg{\"u}elles},
  journal={International journal of medical microbiology : IJMM},
  year={2009},
  volume={299 6},
  pages={
          453-64
        }
}
  • María Martínez-Esparza, Encarnación Martínez-Vicente, +3 authors J. Argüelles
  • Published in
    International journal of…
    2009
  • Biology, Medicine
  • Disruption of the TPS2 gene encoding the only trehalose-6P phosphatase activity in Candida albicans caused a pleiotropic defective phenotype, maintaining the cell wall integrity and the ability to form chlamydospores. A homozygous tps2Delta/tps2Delta showed reduced growth at high temperatures and a marked sensitivity to heat shock (42 degrees C) and severe oxidative exposure (50mM H(2)O(2)). Reintroduction of the TPS2 gene reversed these alterations. A more detailed study of the antioxidant… CONTINUE READING

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