Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1.

@article{Liang2011RoleOT,
  title={Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1.},
  author={Jiexian Liang and Qing Ji and Wenjin Ji},
  journal={Neuroscience letters},
  year={2011},
  volume={492 3},
  pages={175-8}
}
Noxious cold reduces pruritus and transient receptor potential ankyrin subfamily member 1 (TRPA1), a non-selective cation channel, is known as a noxious cold-activated ion channel. Recent findings implicated the involvement of TRPA1 in pain induced by endothelin-1 (ET-1). Therefore, we evaluated its potential role in pruritus induced by ET-1. We found that ruthenium red (RR; a nonselective TRP inhibitor) and AP18 (a TRPA1 antagonist) significantly increased scratching bouts caused by ET-1… CONTINUE READING

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