Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver.

@article{Thenappan2010RoleOT,
  title={Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver.},
  author={Arun Thenappan and Ying Li and Krit Kitisin and Asif Rashid and Kirti Shetty and Lynt Johnson and Lopa Mishra},
  journal={Hepatology},
  year={2010},
  volume={51 4},
  pages={1373-82}
}
UNLABELLED Adult hepatic progenitor cells are activated during regeneration when hepatocytes and bile duct epithelium are damaged or unable to proliferate. On the basis of its role as a tumor suppressor and in the potential malignant transformation of stem cells in hepatocellular carcinoma, we investigated the role of key transforming growth factor beta (TGF-beta) signaling components, including the Smad3 adaptor protein beta2-Spectrin (beta2SP), in liver regeneration. We demonstrate a… CONTINUE READING

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